Biotech gears up for 'launch year' in 2008 - Memphis Business Journal:

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Some companies have already gotten those golden government approvals to finally sell their Some willget them. Some will finally know the next step in the Some will waitand see. "2008 will be a big launchg year in Memphis in the lifesciencez category," says Innova president Ken launched its hip implant in Europee at the tail end of 2007. Extremituy Innovations, Inc., is readyiny to sell its Innopad injectable foot implang in a few months pendingEuropean GTx, Inc., will get new data on different dosagezs of Acapodene, the drug associated with prostate and hopes the government will let them sell it by 2009.
ArGentids Pharmaceuticals LLC will either put its dry eye treatmenrt in clinical trials or outlicense it to a largw investor and is in talkxs with investors relating to its treatmengfor scleroderma. The general tenor among all ofthese Memphis-based biotechs is summed up by Extremityu Innovations president Joe Clift. "It's a lot of hard work and but we're excited and we thinko the end result will be worth it for the patien t population andfor us," Clift The gate on Active Implants' Tribofit hip system was openedc in late December, but company officials didn't expecr it to buck so hard so "We didn't expect the growth to be happening right chief financial officer Dennis Long "It feels great knowing now that you'vse got some money coming in from customers, not just Also good to know that your markety is growing rapidly and you have a stream of productxs to support it.
" So far in 2008, the companty has hired Troy Drewr y as vice president of global operations and has electe industry veteran Jack Blair as chairman of its The company will also continue to develop its seconxd product, a meniscus implant for Clift, from Extremity Innovations, says he hopews European approval of Innopad will come sometime this Should the government grant that approval, he says the companh will take the injectable implanf first to England and then to other major Europeaj markets. The company's first sale could happen by year's end, he but nothing is certaijn when dealing withinternational agencies.
The company is now in negotiation s with distributors to get its productr in the hands of doctors as soon as After pharma giantMerck Co., joined GTx's party last year, the Memphis-bornj drug company has a little more cash on hand but 2008 doesn'tf look like a big money-making year for New data is due in different dosages of Acapodene this year, althougbh it won't hit the shelves in 2008.
Data from the Phasr III trial, the final FDA trial, of 80 milligran doses of Acapodene will be out bythe year'sa first quarter as the last patient has completed the With that, the company hopeas to file a new drug application by the secon d half of the year and perhaps ring its firsy sale in 2009. That dosage treatz the side affects of androgendeprivationj therapy. Trials will continue on GTx'ss 20 milligram dose of Acapodene whether or not new data due out this year is positiveeor inconclusive. That dosage treats the prostatdin pre-cancerous stages. If the data is positive, then the companyg will likely file a New Drug Application with the FDAby year'xs end.
If the data is inconclusiv e then the trial will continue until the final So farin 2008, GTx signer a 30,750-square-foot sublease at the Toyota Center It will take the entire seventh floo r and half of the eighth floor. A companyt official said the company "is bursting at the at its Midtown headquarters, but has no plans to move thatheadquartersw Downtown. The deal with Merck in Novembe r gaveGTx $40 million upfront, with $15 million in researcgh reimbursements over the firsy three years. Merck investede $30 million in the company's commoh stock and GTx can get upto $422 millio in future milestone payments.
Whiled most of these companies aresimplg waiting, ArGentis is waiting and seeing. Compangy officials are thinking about the future of their dry eye They know if they wait and put the gel treatment inclinical trials, it will be more valuable to investors. But whilee they've been talking with clinicalk research organizations to get thoswtrials started, they've also been talkin g with potential partners to outlicensd the science. "We believe it woulr take somebody of some size to be able to take thosse productsto market," says chief financialp officer Buddy Lyons. "So we're approaching the treatmenta fromboth angles.
"

UNM Cancer Center finds leukemia mutation - New Mexico Business Weekly:

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The mutation was found in genew that producekinases (a process referrer to as JAK), which are enzymes that functiobn as biological on-off switches in ALL occurs when white blood cells that fighg off viruses and bacteria don’t mature properly. These underdeveloped cells builx up and crowdout healthy, infection-fightingb cells, the Cancer Center said in a news release. The mutatiohn underlying that process was found in about 10 percen of the cases theresearchers studied. ALL accounts for 75 percent of all childhoosdleukemia cases.
An average of 37 ALL cases are diagnosex in New Mexicoeach year, the Cancer Center “What’s really exciting about this particula study is that we found that druga that blocked the activity of the mutant JAK process preventex uncontrolled cell proliferation,” said Dr. Cheryl director and CEO of theCancer Center. “Our discoverg of JAK as a target now allow us to develop clinical trials with JAK inhibitors for childrem and adults with this formof disease.” The Cancef Center worked in collaboration with , the National Cance Institute and the Children’s Oncology Group/CureSearch. The finding appears online in the early edition of the Proceedings ofthe .

Nonprofits prepare for a share of broadband stimulus funds - Denver Business Journal:

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billion of the American Recovert and Reinvestment Act allocated to provide broadband accesws to unserved and underservede populations acrossthe nation, the region’s nonprofits are scramblinf to bring a share to South Florida. Though the federa l government hasn’t decided the rules for disbursing the money, advocates have been strategizing for months on ways to bridgre the digital divide and increase the region’s competitiveness by completing new project s and expanding existing ones. But, getting South Florida fullu wired won’t be easy.
With ideas ranging from providinyg free broadband access for disadvantaged students to putting government agencies ona single, high-speed network and outfitting emergency responderx with mobile Wi-Fi, the challengd is to pursue those initiativess most likely to succeed. One existing prograjm hoping to capitalize on stimulus money isFloridaq LambdaRail, a Tallahassee-based nonprofit cooperative of education and research organization s that share a broadband connection, whichy allows them to save money.
, , , and use the ultra-fas LambdaRail, but the cooperative is lookinyg to expand its services to benefit othernonprofiy agencies, CEO Phil Halstead There are too many unserveds or underserved people in Florida, he said, noting many institutions could streamlinse costs and increase speed by using LambdaRail. “The statse is seeking a Halstead said. “We’re trying to create an Eisenhowe r interstate systemfor broadband.” To that end, LambdaRaikl is to host a “broadban summit” at FAU on June 16. The summit will bring togethe technology chiefs to study ways to expand use ofthe LambdaRail.
Questionx of how to get stimulus money and what to do with it will loom largwe overthe summit, Halstead said. The $7.2 billionb up for grabs for broadbands will be split betweenthe U.S. ($4.8 billion) and the ($2.5 billion), said Linda Gov. Charlie Crist’s deputy coordinator for stimulud funds. The Agriculture funds are supposed to targegtrural populations, while the Commerce money will be a little more flexible. Even so, Fuche cautioned that the federal government is still deciding how to distribute the It is unknown whether funds will go through the as is the case with transportationstimulusd money, or directly to local applicants.
And, unlike the transportationb funds, broadband money will be dolerout competitively. In other words, Soutb Florida may not see a dime, Fuchx said. To maximize their each county has a nonprofit agencymakinv plans. The Miami-Dade Broadband Coalition developed a workintg proposalin December, said Kim chairwoman of the coalition’s interim executivew committee. There was aboutg $200 million worth of need identified, she One idea under consideration is to expand Elevate a city of Miami program that targetwsthe county’s underserved. Another possibility is providing low- or no-cost broadband accessx for the homes ofdisadvantaged children.
The coalitiohn would also like to createa “telemedicine in county schools, allowing doctors to examine studentw through video conferencing, Marcille In Broward, county organizations could reduce waste by consolidating on a shared broadband pipe, instead of payingh for services separately, said Phyllis Schiffer-Simon, president of a nonprofit digital advocacy “We’d be creating our own OneBroward’s working proposals would cost about $25 Schiffer-Simon said. Chuck Spalding, projec manager for the Palm BeachgBroadband cooperative, said the county coul d use stimulus money to provide free Wi-Fi accesse to the homes of disadvantaged students.
Another idea is to link governmenft and nonprofit agencies in rural areasx to acentral network, such as the “We can provide them with dramaticallyu increased bandwidth over what they currently have at abouy one-third the cost,” he said.

Republicans trying to turn back clock on bedrock environmental protections - The Hill

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Republicans trying to turn back clock on bedrock environmental protections The Hill It uses border control as cover behind which to hide the Republicans' real ambition, which is to turn back the clock on our bedrock environmental protections. Another of their efforts, the “Wilderness and Roadless Area Release Act,” would open up as ...

Tourism group honors best of tourism promos - Charlotte Business Journal:

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The Tourism Industry Association Recognition orTIARA Awards, highlight excellence and creative accomplishmenyt in travel marketing and promotion. The Farmingto Convention and Visitors Bureau, whic h hosted the TANM conference, took home the award for . The village of Chama won an honorable mention for itsvisitor guide. The best went to the Chocolate Turtle Bed Breakfastin Corrales. Buffalo Thunder Resort Casino receivedhonorable mention. Buffalo Thunder took top honorse for best print advertising and for outstanding new evengt for its grand opening last The Rio Rancho Conventionand Visitor’ Bureau “Pork & Brew” was named top outstanding recurring event.
Roswell’se UFO Festival earned an honorable mentiojn inthat category. The most innovative promotion awarxd went to the Albuquerque Convention and Visitors BureauHolidaty Video, “Life of a Brown Papere Bag.” The award for most successful publicc relations effort was divided into thre categories. Bishop’s Lodge Ranch Resorrt & Spa won the private sector category for its 90thanniversary celebration. The Albuquerqus Convention and Visitors Bureau earned top kudos forits , with the town of Taos taking honorable mention for its annual public relations campaign.
And the top awardr for press tours went tothe state’sa North Central Tourism More information is available at TANM's . Next year’a Governor’s Conference on Tourism, co-sponsored by TANM and the New MexicooTourism Department, will be at Buffalo Thunder Resort & Casinko in Santa Fe, April 19-21.

Home sweet abode: Shop owner learns lessons - The Business Journal of Milwaukee:

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But Adamec learned quickly thatfunk pillows, scented candles and fancy stationery don’t pay the billsz for her store, , in downtown “Looking back, I had some really goofy inventory picks,” Adamec said. “Now I reallty watch my inventory and have had a greattturnover rate. I don’t buy it unles s I’ve already got half of the load sold.” By returninf to her interior design roots, 37, has not only been able to makea profit, she has a growinv list of clients who want to tap into her expertise in home Since opening Urban Abode, 336 W. Main St. in Septemberr 2004, Adamec has cut back the store’s hours to threew days a week fromsix days.
Now the store is open Fridaysand Saturdays. The decision to restrict the store’s hours was one of the hardest business decisions she had to she said. Adamec spends Tuesdays, Wednesdaya and Thursdays with clients, developing concepts for their decorating Adamec chargescustomers $125 for the initial home visit and then $79 an up to $1,000, to develop a concep t plan for the home. Customers then pay for the servicesdthey choose. Adamec also does paint charging $30 per room, which does not include the cost of paingor labor. The shift from strictly retailp to a combination of retail and interior design haspaid off.
Adamec had annual revenue of $250,000p in 2007, which was the firsty time since opening the store that she madea “It was a teensy but a profit nonetheless and I’m very proud of she said. Before opening Urban Adamec worked at Furnitur e Express inFort Atkinson. She also spent six yearse at the now closed Country Craft and nine years at Steinhafels furniture storein Waukesha, where she was a merchandisre manager at both stores. As merchandise Adamec assisted the buyers in producft selection and made her own suggestionxsfor inventory. Adamec spent 10 years thinking about opening her own businesas before actuallydoing so.
When she realizeed her interior design degree from did not give her the backgrounxshe needed, Adamec returnedr to school. She graduated from in Milwaukee in 2000 with a double major in businesz managementand history. Adamec learned to writse a business plan at and worked on her plan for Urban Abode for four yearse before applying fora loan. Four bankzs turned down Adamec before took what Adamec calls a grea t risk and loanedher $80,000. Adamec also liquidated her retirement plan and used her house as collateral to come up with an additional $25,000 — a risk she herseldf would not have taken if she wasn’t single.
“ wasted so much money that first year, buyintg things I didn’t need, so I reallgy struggled my second year,” Adamec said. “I’m stilll paying on that original loan, but now I have gotten to the pointr where themoney I’m generating is supporting me and the In June, Adamec hires her first employee, another designer she is hoping to have traines by the fall. The additionalo help will give Adame c somebreathing room, something she hasn’t had in recent Adamec just completed decorating a home for Tony owner of West Allis-based , for the ’w 2008 Parade of Homes. Adamec won top honore for interiordesign Aug.
27 from the MBA for the a 3,200-square-foot, two-story, four-bedroom home at S78 W14883 BellseChasse Parkway, Muskego. Alesci said the home is decorated usinyg a palette offive colors: turquoisd blues, browns, sage, brick and gold. While each room is a different color, that palette is used throughout the Alesci said. “She (Adamec) is very but uses a lot of clean linee making it colorfulbut simple,” Alesci “Some designers just want the visitor to see the interior designm and not the house. Her design totally complementsxthe house. It’s not a surprises her businessis successful.
”

PwC hires CBRE for relocation opportunities - Atlanta Business Chronicle:

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Doosan Infracore is Korea’s largest manufacturer of construction Doosan agreed to a term of eight yearsw and four months in North owned by RubensteinPartners L.P. Askin rents are almost $25 per squar foot at the building.The value of the excludingconcessions, is about $5 million. Doosan Infracore was established in 1937 and specializew inconstruction equipment, industrial vehicles, defense product and machine, diesel and natural gas systems. Doosaj Infracore employs about 5,000 people, and has plants arounfd the world.
Monty Harris with Newmark Knighy Frank and Brent Royall with Keystone Partnerd LLC represented Doosan Infracore in the lease at North Caroline Nolen and Andy Sumlin of Barry Real EstatsCompanies Inc. represented Rubenstein. Barry Real Estat e is in charge of marketing thetwin 11-storuy Terraces buildings near Perimeter Mall. — Staftf writer Lisa R. Schoolcraft contributed to this

Emergent BioSolutions anthrax vaccine gets boost - Business First of Buffalo:

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The Rockville-based company’s BioThrax has been granted a shelf life extension from the from its current threse yearsto four. Under its contract with the Department of Healtgh andHuman Services, the extension triggers a milestone payment of $30 million for dosesx of the vaccine already deliverer to the Strategic National Stockpile. Emergent expects to recorcd that payment as revenuethis quarter. The shelv life extension also allows Emergent to charge more for futurd doses of the vaccine delivered tothe government’sw stockpile. That could raise the value of the contracft to as muchas $405 milliobn over the next several years.
Last year, the FDA approvesd a reduced vaccination schedule tofive doses. Emergent continues researchy that could lead to a further reduction in the numbet ofdoses required, as well as the vaccine’se use to treat patients aftee being exposed to Anthrax, not just as a pre-exposurw vaccine. Emergent has supplied the government’ s stockpile with 33 million doses of BioThraxso far. It is contractes to continue adding to stockpiles throughlate 2011. BioThraxc has been used to vaccinate more than 2 million militaryg personnel since the government first started buyingy the vaccinein 1998. Emergent stock (NYSE: EBS) was up 90 centes to $14.63 per share in afternoonj trading.

Mariner Holdings gives Tortoise Capital Advisors an energy boost - Kansas City Business Journal:

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will buy a 65 percentr stake inthe Leawood-based company for an undisclosed sum, the companies announced June 3. When completed, probabl y in the third quarter, the deal will put Marinert well on the way to a goal stated in earlyt 2008 ofhaving $5 billion in asset s under management in five Mariner Holdings and executives with Tortoise Capital Advisorx agreed to buy all interests from and . Tortoise managing directors Kevin Birzer, Zachary Hamel, Ken Malvey, Terry Matlack and Davic Schulte will own 35 percengt ofthe company, and four other senior managersd will be eligible to buy a stake in Tortoise through an equity ownership plan.
Tortoise advise s four publicly tradedfunds — (NYSE: (NYSE: TYY), (NYSE: TYN) and (NYSE: TTO). The funds specialize in masterflimited partnerships, or MLPs, in companies involvex in the energy infrastructure industry.

Kaiser Permanente OKs $13M in Q1 community grants - San Francisco Business Times:

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In times of great need, “we must strengthenh support for the most vulnerables people inour communities, such as the uninsuredc and the elderly,” said Raymond Baxter, Oakland-baserd Kaiser’s senior vice presidenrt for community benefit, research and health The specific grants mentioned in Tuesday’s statement were all locate in Southern and central California, Colorado and rather than Northern where the giant health-care system is based and has roughlt 3.4 million enrollees.
However, Kaiser spokesman Joe Fragol told the San Francisco Busines s Timesthat Kaiser’s Northern California regio n is actively involved in the Specialtyy Care Initiative mentioned in the release, and that Kaiserf has committed ten grants totalling $7.5 million to those projects. But because some of the Northern Californiaa grants were approvedpreviously “and others will be approvexd later this year, they were not Fragola said in an email to the Business Fragola said Kaiser will focu s on supporting Northern California entities that provide critical health and humann services to vulnerable populations, including community public hospitals and other safety net systems.
Grantees in Northern Californiw include Alameda CountyMedicap Center, the Marin Community Clinic, San Francisco General Hospital Foundation, San Mateo Medica l Center, the Solano Coalition for Better CommuniCare Health Centers, the Community Clinic Consortiumk of Contra Costa and Solano Counties, Community Health Partnershipsx of Santa Clara, Fresno Healthyu Communities Access Partners and Health Plan of San according to Kaiser. In Tuesday’s announcement, Kaiserr said it gave $900,000 each, for a total $4.5 to five “lead agencies” througyh the California Specialty CareAccesse Initiative: , , , and .
Officials said thosd grants are part ofa 2-year-old statewided program initiated and led by Kaiser to increase access and reduce demand for specialty care amontg uninsured and underinsured populations. They specificallyy target access to care in specialties suchas gastroenterology, neurology, ophthalmology, and cardiology. On otherf fronts, Kaiser said it is giving: $250,000 to implement electronic health records atthe , a clinid in Hillsboro, Ore. $127,800 to the Colo.
-based for an “evidence-based model” to addresss disparities in treating $100,000 to the ’s Elder Caregivers in Los Angeles andOrange counties, to trai n 100 South Asian caregivers focusing on aginbg issues and culturally sensitive care. $275,000, in two grants, to the Universitgy of California, Irvine’s Center for Excellence in Eldefr Abuseand Neglect, including $125,000 to support a pharmacy pilot curriculumj on elder abuse, and $150,000 to help establish a statewidse . $240,000 to the for its ’s Fall Preventionm Center of Excellence $150,000 to Portland, Ore.
’s to develop its Micrl Mercantes Cooperative, an initiative promoting the sale of nutritious food at locaolfarmers markets. $244,824 to Mercy Corps of Portland to developoits “Building Freedom throug Lifelong Information For which aims to help former female convicts to achieve economid stability.

Xcel seeks 7.8% summer rate hike to cover higher costs - Kansas City Business Journal:

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percent temporary rate hike for smallk businesses and homes to cover higher energy prices this Thepower utility’s so-called “electric commodity adjustment” is intended to cove an expected $54.8 million in higher fuel and purchased-energy pricea for the third quarter of 2009. Xcel said that a typica small-business customer using 1,025 kilowatt-hours a month would see current billsa increaseby $7.48 a month, to $101.83. A typicapl residential customer using625 kilowatt-hours a month wouldf see a $4.56 increase, to $63.05.
If approved by the , the rate hike wouldc take effect July 1 and continue for three Underutility rules, Xcel passes along energg cost increases or decreases to customers on a dollar-for-dolla r basis through the quarterly electri c commodity adjustments. The new request is separated froma $112.2 million Xcel electric-rate hike alreadyg approved by the PUC that also takes effectt July 1. That rate increased is to helpthe Minneapolis-basedd utility (NYSE: XEL) recoup some $1.7 billionb it’s spending on generation, transmission and distributionj upgrades for Colorado.

Gourmet on the go: Moveable Feast hits the Event Center this evening - San Mateo Daily Journal

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San Mateo Daily Journal

Gourmet on the go: Moveable Feast hits the Event Center this evening San Mateo Daily Journal On Friday, both Naked Chorizo and Hiyaaa! will be at Moveable Feast, a festival featuring 24 food trucks at the San Mateo County Event Center. Moveable Feast will be the largest scale food truck festival ever held on the Peninsula, according to Ryan ... and more »